Interestingly, MYC induces a stem-cell like miRNA signature in aggressive hepatoblastomas, characterized by repression of miR-100/let-7a-2/miR-125b-1 and activation of miR-371 (part of the human homolog of murine miR-290-295), suggesting that MYC-mediated regulation of miRNAs in PSCs is partly shared with cancer cells and functionally relevant for tumorigenesis. The gene discussed is MYC; the disease is hepatoblastoma.