Additionally, in lymphoma cells, MYC directly binds let-7 and represses it, while, in turn, mature let-7 inhibits MYC expression, suggesting that these two factors are involved in a double-negative feedback regulatory loop (Chang et al., 2008, 2009; Marson et al., 2008; Melton et al., 2010; Zhong et al., 2010). The gene discussed is MYC; the disease is lymphoma.