Using two distinct syngeneic tumor models in different mouse strains, namely intradermal injection of VEGF-C overexpressing B16F10 melanomas and an orthotopic breast cancer model (4T1), we found that PDL1 is significantly upregulated in peripheral, tumor-associated LVs, presumably in response to IFN-g secreted by cells present in the tumor stroma. This evidence concerns the gene VEGFC and melanoma.