IL10 and Other metabolic disease: These intestinal cytokine changes in diabetic rats were consistent with the data in clinical trials; namely, intestinal cytokine’s milieu of healthy persons features high levels of sIgA and IL-10 (Fritz et al., 2012) while that of subjects with metabolic disease features increased proinflammatory cytokines in the intestinal LP and epithelium (Garidou et al., 2015).