Several studies have demonstrated QCT markedly inhibited the development of hypertension in hypertension mouse model and the antihypertensive effects of QCT may be due to enhanced eNOS activity and decreased NADPH oxidase-mediated superoxide anion (O2) generation associated with reduced p47 expression (Duarte et al., 2002; Sanchez et al., 2006). Here, FMO5 is linked to hypertensive disorder.