Extracellular superoxide dismutase (SOD3) has anti-oxidative, anti-inflammatory, anti-apoptotic, and growth promoting characteristics, exhibiting the most potent therapeutic responses and growth regulatory characteristics in cardiovascular and cancer models11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22. Here, SOD3 is linked to cancer.