DDX5 and Familial prostate cancer: DEAD (Asp-Glu-Ala-Asp) box helicase 5 (DDX5) is an ATP-dependent RNA helicase that is overexpressed in various malignancies, such as prostate cancer, breast cancer, colon cancer, non-small cell lung cancer, and glioma4, 5, 6, 7, 8.