IGFBP7 and cancer: Recently it has been shown that miR-124 is down-regulated by DNA methylation in cervical cancer progression showing a higher DNA methylation in Step 3 of cancer progression and cervical cancer than in High-Risk Human Papillomavirus (HR-HPV)-positive tissues [92,93,94] causing Insulin Like Growth Factor Binding Protein 7 (IGFBP7) increase at the mRNA and protein level [92].