IGHE and Alzheimer disease: A significantly higher percentage of eosinophils in the differential white cell count (p = 0.039), the logarithm of serum total IgE (p = 0.008), and the serum concentrations of IFN-γ (p = 0.005) and IL-18 (p = 0.007) were observed in patients with severe AD compared to those with moderate AD (Table 2).