TGFB1 and Pruritus: Associations were also demonstrated with disease extent and IL-18 (an APC cytokine; B = 0.438, p = 0.001), TGF-β (a Treg cytokine; B = −0.015, p = 0.001) and IL-23 (B = −2.812, p = 0.006); pruritus and IL-23 (an APC cytokine, B = 0.387, p = 0.007); TEWL and IL-18 (B = 0.040, p = 0.010).