CCL2 and neoplasm: It is demonstrated that most of the tumor cells express the protein termed monocyte chemotactic protein-1 (MCP-1) who recruited the TAMs into the tumor stroma although we should not ignore the crucial role of tumoral M-CSF (macrophage-colony stimulating factor), angiopoietin-2, VEGF (vascular endothelial growth factor) and MIP-1α (macrophage inflammatory protein 1α) in this way [74,83].