Additionally these cells secrete the hepatocyte growth factor (HGF) in a level higher than the normal fibroblasts [59].CAFs-secreted CCL-2, -5, -7 and CXCL16promote the migration and invasion of HCC cells and facilitate their metastasis to the bone, brain and lung in severe combined immunodeficiency SCID mice by activation of TGF-β signaling pathway [60]. This evidence concerns the gene HGF and hepatocellular carcinoma.