It has been reported that systemic administration of 5′ ppp-siRNA for B-cell lymphoma-2 (Bcl-2) silencing, results in melanoma tumor growth inhibition due to the downregulation of Bcl-2 and immune activation of the RIG-I signaling pathway, this anticancer response requires dendritic cells (DC)-dependent production of IFN-α and recruitment of natural killer (NK) cell at the tumor site [28]. The gene discussed is BCL2; the disease is melanoma.