CCL2 and acute lymphoblastic leukemia: In particular the role of CCL2, IL-6, and IL-8 merits further study; the fact that IL-8 and CCL2 are upregulated in MSC from ALL patients [23], and that plasma levels of CCL2, IL-8, and IL-6 are increased in children at ALL diagnosis [23,31], show their relevance in vivo and validates in part our in vitro LN.