In an effort to more accurately define disease multiple groups [117], including the TCGA consortium, have added to previous understanding [118,119] and established roles for common genetic alterations in PCa [120,121,122], and novel somatic mutations, including Forkhead Box A1 (FOXA1), Speckle-Type POZ Protein (SPOP). The gene discussed is SPOP; the disease is posterior cortical atrophy.