ASCC3 and Cockayne syndrome: However, in a manner similar to knockdown of Cockayne syndrome B (Figures S4D and S4E), knockdown of ASCC3 short isoform inhibited transcription recovery, as indicated by a marked general change in the characteristics of nascent transcription across the cell population (Figure 5A, 20 hr panel), and consequently an increase in the ratio of lowly to highly transcribing cells after UV irradiation (Figure 5B).