SYNE1 and Emery-Dreifuss muscular dystrophy: To determine if any particular one of these proteins is recurrently defective in its intracellular distribution we stained a panel of 3 control and 8 EDMD patient myoblast/fibroblast cultures (Table 1) for emerin, lamin A/C, nesprin 1, nesprin 2, SUN1, SUN2, and FHL1.