In the present study, we have analyzed the effects of low dose treatment (5–20 μM) of ursolic acid (UA) and betulinic acid (BA) on breast cancer cells of different receptor status, namely MCF-7 (ER+, PR+/−, HER2−), MDA-MB-231 (ER−, PR−, HER2−) and SK-BR-3 (ER−, PR−, HER2+). This evidence concerns the gene ERBB2 and breast carcinoma.