Individuals with these very specific missense NF1 mutations exhibit CALS (with or without freckling)and Lisch nodules, but no externally visible plexiform neurofibromas or cutaneousneurofibromas (Pinna et al. 2015;Rojnueangnit et al. 2015).Approximately, 25% of the individuals with missense mutations affecting codonp.Arg1809 have Noonan-like features including pulmonic stenosis and short staturewhilst 50% of them exhibit developmental delay and/or learning disability(Rojnueangnit et al. 2015). This evidence concerns the gene NF1 and Global developmental delay.