Although the deletion ofSUZ12 may well predispose patients withNF1 microdeletions to malignancy, in particularto the development of MPNSTs, the reasons for the disproportionately higherfrequency of benign plexiform, subcutaneous and spinal neurofibromas in patientswith NF1 microdeletions is still unclear. Here, NF1 is linked to Spinal neurofibroma.