In glioblastomas, however, RNF135 has been found to be upregulated and promotes theproliferation of human glioblastoma cells in vivo and in vitro via the ERKpathway (Liu et al. 2016).Furthermore, RNF135 would appear to promotethe expression of PTEN and TP53 in tongue cancer SCC25 cells and RNF135 overexpression inhibits the viability,proliferation, and invasion of these cells (Jin et al. 2016). This evidence concerns the gene RNF135 and tongue cancer.