The MPNST cell line analysed bythese authors was derived from an NF1 patient but the germline NF1 mutation in this patient had not been determined.In similar vein, whilst Pasmant et al. (2011) observed high COPRSexpression in a series of MPNST cell lines as compared with plexiform andcutaneous neurofibroma samples, in other MPNST cell lines, COPRS expression levels were as low as in plexiformand cutaneous neurofibromas (Pasmant et al. 2011). The gene discussed is NF1; the disease is plexiform neurofibroma.