Several studies have suggested that patients with NF1 microdeletions not only exhibit a high number ofcutaneous neurofibromas but also an early (pre-pubertal) onset of cutaneuousneurofibroma growth (Kayes et al. 1992, 1994; Mensinket al. 2006; Leppig et al.1997; Dorschner et al.2000). The gene discussed is NF1; the disease is plexiform neurofibroma.