However, thetype and frequency of the heart defects observed in patients with NF1 microdeletions are quite heterogeneous, includingpulmonic stenosis, ventricular septal defect, aortic stenosis, atrial septaldefect, aortic stenosis, mitral valve prolapse or insufficiency, and hypertrophiccardiomyopathy (Table 2). This evidence concerns the gene NF1 and aortic stenosis.