The rescue effects of 3MeA on autophagy [LC3-II-to-β-tubulin ratio and LC3-positive cells (Fig. 4)] and especially on cell death (Fig. 3) may indicate an ALS-hMSC-specific aberrant regulation of autophagy causing it to be cytotoxic, rather than cytoproective as it is in HC-hMSCs. Here, MAP1LC3A is linked to amyotrophic lateral sclerosis.