Methylation in this locus (at cg06500161) has previously been associated with prevalent myocardial infarction.39 The ABCG1 gene product functions in the efflux of cholesterol from lipid-loaded macrophages to HDL-C.58 However, the functional basis for association to levels of triglycerides in blood circulation is unclear. This evidence concerns the gene ABCG1 and myocardial infarction.