Twenty-five of the 33 replicated CpGs have not been previously reported to be associated with lipid levels.38,39 Novel sites included those near genes with a known function in cholesterol metabolism (DHCR24, SREBF2, and SQLE) and with a possible role in atherosclerosis (endothelin-converting enzyme-1).51,52 The novel genes identified warrant further research as potential targets for perturbation to reduce dyslipidemia. The gene discussed is ECE1; the disease is atherosclerosis.