When exploring whether methylation at lipid-associated CpGs has also been associated with related cardiometabolic traits, we found overlap with associations for adiposity (near genes ABCG1, CPT1A, DHCR24, KLF13, MYO5C, PHGDH, SREBF1, and VPS25),53–55 glycemic traits (near ABCG1,)56 and type 2 diabetes mellitus (near genes SREBF1, ABCG1, and TXNIP).57 In addition, we observed associations of circulating lipids with DNA methylation levels at CpGs near genes previously reported to be associated with lipids, other cardiovascular traits, and CVD events in GWAS. Here, VPS25 is linked to diabetes mellitus.