Many lipid-associated CpGs in our study were annotated to genes in loci highlighted in GWAS of cardiovascular traits, including lipids (AMPD3, APOB, FADS2, GALNT2, LDLR, MYLIP, and TRIB1), waist:hip ratio (CBX3, KLF13, and LY86), BMI (ADCY3), adiponectin (TRIB1), type 2 diabetes mellitus (PTPRD), and CHD (APOB and LDLR; Table XIII in the Data Supplement). This evidence concerns the gene FADS2 and diabetes mellitus.