ABCG1 and coronary artery disorder: Metabolites associated with methylation of the DHCR24 promoter included a derivate of cinnamic acid, recently shown to be associated with a lower risk of incident CHD events.46 Methylation at the ABCG1 locus was associated with specific ceramides and sphingomyelins, which have been implicated in the development of atherosclerosis and CHD.47,48