Metabolites associated with methylation of the DHCR24 promoter included a derivate of cinnamic acid, recently shown to be associated with a lower risk of incident CHD events.46 Methylation at the ABCG1 locus was associated with specific ceramides and sphingomyelins, which have been implicated in the development of atherosclerosis and CHD.47,48. Here, ABCG1 is linked to atherosclerosis.