We found the relationship of methylation at cg27243685 with triglycerides and risk of CHD to be directionally consistent with the expected based on previous studies of lipid levels and CHD risk.1–3 Hypermethylation at cg27243685 in the 5′-UTR of ABCG1—that was associated with decreased expression of ABCG1 (Table XVIII in the Data Supplement)—was associated with higher triglycerides and lower HDL-C, as well as increased risk for CHD (Figure 2). This evidence concerns the gene ABCG1 and coronary artery disorder.