This methylation marker, which is located at the south shelf of a CpG island in the 5′-UTR region of ABCG1, was associated with decreased expression of ABCG1 in blood, increased triglyceride levels (even after adjustment of BMI and regulated both by blood and SAT methylation), and increased risk of new-onset CHD. The gene discussed is ABCG1; the disease is coronary artery disorder.