However, many normal cell types, including various different immune cells such as monocytes, T cells, natural killer cells, and dendritic cells, have been shown to express TRAIL (Fanger et al., 1999, Griffith et al., 1999, Kayagaki et al., 1999, Mariani and Krammer, 1998, Mirandola et al., 2004) and could therefore contribute to tumor promotion by TRAIL and possibly even provide a positive feedback loop. Here, TNFSF10 is linked to neoplasm.