Paradoxically, both receptors and FADD have recently been independently associated with promoting NF-κB induction and tumor growth, whereas a mechanistic background concerning the involvement of FADD, in particular regarding its effect on the microenvironment, has been lacking (Bowman et al., 2015, Tang et al., 2009, Trauzold et al., 2006). This evidence concerns the gene FADD and neoplasm.