FADD and hepatocellular carcinoma: Although FADD is a crucial mediator of apoptosis, it has been implicated in facilitating tumor promotion in hepatocellular carcinoma (HCC) and is associated with a poor clinical outcome in head and neck cancer and NSCLC patients (Bowman et al., 2015, Ehlken et al., 2014, Rasamny et al., 2012).