Given that CK7 is consistently stained in the SCJ cells and the upper layer cells in immature metaplasia and all grades of CIN [2–4, 16], it would be assumed that CK7 positive cells in the luminal side of an invasive cancer nest (SCC#19) might be the cells line in this sequence. The gene discussed is KRT7; the disease is cervical squamous intraepithelial neoplasia.