CD4 and early-onset autosomal dominant Alzheimer disease: Two HIV+ cases had particularly high expression of these genes, both black females (ages 58 and 69) with histories of illicit drug use, last CD4 cell counts < 300 cells/μL, on HAART with last plasma VL < 400 copies/mL: one had endocarditis and sepsis with microemboli in multiple organs including brain, while the other had Alzheimer’s disease pathology and positive AmyloGlo staining. Given these comorbidities, increased IFN-response gene expression in these two cases was not clearly attributable to HAND.