In late carcinoma, Pparg was among the 26 down-regulated PPAR pathway genes (Cd36, Sorbs1, Pparg, Angptl4, Lpl, Fabp4, Acox1, Acadm, Me1, Cpt2, Slc27a1, Scp2, Adipoq, Acsl1, Fabp3, Ppara, Plin1, Cyp27a1, Acox3, Pltp, Pck1, Ilk, Aqp7, Rxrg, Cpt1c, and Nr1h3); Cyp2e1 was among the 17 down-regulated drug metabolism-related cytochrome P450 genes (Mgst3, Ugt1a9, Adh1c, Fmo1, Gstz1, Aox1, Cyp2e1, Gsta3, Gstt2, Maob, Cyp2d6, Fmo2, Gstm1, Ugt1a5, Ugt1a3, Gstm2, and Aldh3b2). The gene discussed is CYP2D6; the disease is carcinoma.