Of the 79 E2F targets we identified in late carcinoma, 14 genes (H2afz, Spc24, Cenpm, Gins1, Pola1, Prim1, Nop56, Kif18b, Mms22l, Lyar, Tcf19, Cdca3, Trip13, Ncapd2) are not previously described in breast cancer. The gene discussed is POLA1; the disease is breast carcinoma.