ESR1 and breast carcinoma: Therefore, by summarizing the canonical pathways that are highly correlated with BC and that are among the potential targets, the 10 herbs might achieve anti-breast cancer activity primarily through the following routes: 1) blockade of estrogen action via ER (estrogen receptor) antagonism; 2) blocking the nuclear translocation of the ER; 3) leading to degradation of the ER and oncoproteins through dissociation from HSP90; 4) blocking the transcriptional activity of AP-1 and the ER; 5) regulating the function of translation products by AP-1 and the ER.