When assessing the Mcpt4/Mcpt6/Cpa3 multiple knockout (KO) strain in our model, we noted that the melanoma colonization of lung tissue was markedly higher than in WT mice (Figure 1B-1C), suggesting that the combined action of Mcpt4, Mcpt6, Cpa3 and Mcpt5 is protective against melanoma dissemination to the lung. Here, CPA3 is linked to melanoma.