Many of these drug classes overlap with those to which SLFN11-expressing SCLC cell lines are sensitive, although E-cadherin and SLFN11 levels were not strongly correlated (R=0.233, P=0.058; Supplementary Figure 7B), suggesting that EMT and SLFN11 contribute independently to drug response. This evidence concerns the gene CDH1 and small cell lung carcinoma.