The higher response rate of E-cadherin high SCLC to BCL2 inhibitors (e.g., ABT-737, ABT-263, venetoclax) corresponded with higher BCL2 mRNA expression in the E-cadherin high cell lines and tumors, suggesting that BCL2 levels or EMT status could be used to help select patients for treatment with BCL-2 inhibitors and that pharmacologic strategies to reverse EMT may enhance BCL-2 inhibitor activity. Here, CDH1 is linked to small cell lung carcinoma.