Furthermore, cisplatin treatment of lung adenocarcinoma cell lines with high endogenous levels of SLFN11 showed a subsequent reduction in expression (A549, P=0.002; H1944, P<0.0001; HCC827, P=0.001), but not those with low levels (Calu6, P=0.785; Figure 2C). The gene discussed is SLFN11; the disease is lung adenocarcinoma.