Thus, in the current study, an autophagic molecular mechanism of Tan I was elucidated by assessing the essential effect of p62ΔUBA domain andprotein- protein interactions between p62/SQSTM1 and JNK or IRE1 in H28 and H2452 malignant mesothelioma cells. The gene discussed is SQSTM1; the disease is malignant mesothelioma.