Sequencing projects have also identified potentially pathogenic mutations of the known tumor suppressor genes CDKN2A, TP53, NF2, and PTEN in a subset of ccRCC tumors [9] as well as mutations in PI3K pathway regulators mTOR and PIK3CA, frequently abolished in many cancers [14]. This evidence concerns the gene PIK3CA and nonpapillary renal cell carcinoma.