In this study, we performed IHC analysis of S100A7 in normal cervical tissue, cervical cancer and CIN and found that the staining of S100A7 was scattered, suggesting that S100A7 displays the cellular heterogeneity in cervical cancers, which is supported by previous study that S100A7 exhibits heterogeneous and inducible characteristic in squamous cell carcinomas (SCC) [24]. This evidence concerns the gene S100A7 and cervical squamous intraepithelial neoplasia.