TLR3 and breast carcinoma: We previously evaluated the ability of endosomal TLR agonists, including poly(I:C) for TLR3 and IMQ, doxorubicin, and gardiquimod for TLR7, to cause autophagy in MCF-7 human breast cancer cells, and found that poly(I:C) and IMQ increased autophagy-induced cell death in response to low-dose IR exposure [13].