This prolonged condition also generates an immuno-suppressive environment by recruiting suppressor cells, including CD4+CD25+Foxp3+ regulatory T cells (Treg) [21], myeloid-derived suppressor cells (MDSCs) [22, 23], tumor-associated macrophages (TAMs) [24], N2-polarized neutrophils [25], and regulatory/tolerogenic DCs [26]. The gene discussed is CD4; the disease is neoplasm.