In agreement with the mechanistic findings in vitro, IHC analysis of tumor tissues demonstrated that combined treatment with RAD001 and AZD6244 resulted in greater inhibition of Ki-67, p-RPS6, p-Erk1/2, and p-4E-BP1 compared with the monotherapy and control groups (Figure 5B). Here, EIF4EBP1 is linked to neoplasm.