We found that BCAA reduced the expression of NFYA and p300 in two mouse NASH models (Figure 4 and Supplementary Figure 2), in two cell lines (Lx-2 and Huh-7 cells, Figures 4C and 5A), and mouse primary hepatocytes (Figure 5C). Here, EP300 is linked to metabolic dysfunction-associated steatohepatitis.