TP53 and central nervous system cancer: The recently updated data from cBioProtal (till December 15, 2016) for Cancer Genomics shows that 39.7% p53 gene mutation exist in 812 merged cohort of LGG tissues and GBM (TCGA, Cell, 2016), the 90.2% mutation of p53 in 61 LGG samples (UCSF, Science, 2014), and 20.3% in GBM (TCGA, Cell, 2013), which may suggest a negative association with the pejorative WHO grades of glioma.