To determine whether the tumor suppressive effects of SNORA74B knockdown are mediated by PHLPP, we knocked down PHLPP by shRNA (Figure 5C) and examined the effects of SNORA74B silencing on the activation of members of AKT/mTOR signaling pathway, as well as on cell viability, cell cycle, and apoptosis. The gene discussed is AKT1; the disease is neoplasm.