Furthermore, univariate analysis identified the expression of SNORA74B as well as local invasion, lymph-node metastasis, distant metastasis, TNM staging, CA19-9 level, Ki67 expression as negative prognosticators for GBC, while PHLPP may serve as a good prognosticator (P < 0.05) (Table 3). Here, MKI67 is linked to metastatic malignant neoplasm in the lymph nodes.