It has been reported that SNORA42 is frequently overexpressed in non-small-cell-lung carcinoma (NSCLS) and colorectal cancer, and that siRNA knockdown of SNORA42 results in reduced cancer cell growth, indicating that SNORA42 is a putative oncogene [4, 5]. The gene discussed is SNORA80E; the disease is non-small cell lung carcinoma.