This two-stage GWAS validates the use of consumer self-report data as a platform for discovery of new cancer-related genes, provides confirmation of 20 out of 21 of the previously known melanoma-associated loci, and identifies one novel susceptibility locus (5p15.1; BASP1) which confers a 1.96-fold increase in risk of melanoma. The gene discussed is BASP1; the disease is cancer.