AKT1 and neoplasm: The phosphoinositide 3-kinase (PI3K)-AKT-mTOR signaling pathway plays an important role not only in the regulation of some crucial physiological cell processes – including cell-cycle progression, differentiation, ribosomal biogenesis and protein translation – but also in the regulation of certain aspects of tumor behavior such as cell growth, survival and chemoresistance [47–49].