This could explain why LEDGF/p75 overexpression in cancer cells typically does not confer protection against insults that robustly activate caspase-3, such as TRAIL and STS, which result in LEDGF/p75 cleavage and inactivation, but does protect against insults that induce LMP and even necrotic cell death, which leave the protein relatively intact [18, 19, 64]. Here, CASP3 is linked to cancer.