PSIP1 and posterior cortical atrophy: Our group and others have shown that LEDGF/p75 is upregulated in PCa and in other human cancer types, and that overexpression of this protein in cancer cells is associated with features of tumor aggressiveness, such as increased proliferation, resistance to cell death and therapy, invasion, migration, clonogenicity, angiogenesis, and tumor growth [11, 15–25].