In addition, since LEDGF/p75 promoted protection against DTX-induced lysosomal cell death and stress-induced caspase-independent cell death in PCa cells [18, 20], we explored if the protective functions of LEDGF/p75 are linked to the ability of DTX and CBZ to activate caspase-independent mechanisms of cell death in drug-resistant PCa pre-clinical models. This evidence concerns the gene PSIP1 and posterior cortical atrophy.