It is well known that the crucial genetic event in CML development is the generation of a t(9;22)(q34;q11) reciprocal chromosomal translocation [34], resulting mainly in the generation of the BCR-ABL (p210) oncoprotein with a constitutive kinase activity [35–37]. This evidence concerns the gene EVPL and chronic myelogenous leukemia, BCR-ABL1 positive.