Over the past years, recurrent gene fusions have been identified in several different salivary gland neoplasms [6–8], including PLAG1 fusions (most often CTNNB1-PLAG1) and HMGA2 rearrangements in pleomorphic adenoma, CRTC1-MAML2 fusion in mucoepidermoid carcinoma, MYB-NFIB (or MYBL1-NFIB [9, 10]) fusion in adenoid cystic carcinoma, ETV6-NTRK3 fusion in mammary analogue secretory carcinoma of the salivary gland, and EWSR1-ATF1 fusion in hyalinizing clear cell carcinoma. This evidence concerns the gene PLAG1 and clear cell adenocarcinoma.