FBL and melanoma: Rs4431401 has been found to modulate expression of small nucleolar RNA host gene 5 (SNHG5) in a genome wide identification study of expression quantitative trait loci (eQTLs) in human heart.[16] Small nucleolar RNAs belong to the long non-coding RNAs (lncRNAs) and regulate rRNA modification mainly by altering the methylation of fibrillarin.[17] The RNA serum level of SNHG5 in particular has been proposed as a new tumor marker of malignant melanoma[18]- a condition which is often associated with calcification[19,20, 21, 22] even in patients with normal kidney function.