The relationship of +405 G/C gene polymorphism of VEGF with essential hypertension and coronary artery diseases in diabetic patients has been reported previously [18, 19]; However, considering the lack of knowledge about the relationship between Mediterranean dietary quality index and VEGF gene polymorphism in patients with metabolic syndrome, further interventional studies are needed to evaluate Mediterranean dietary quality index in patients with metabolic syndrome disease according to various genotypes of VEGF +405 G/C gene polymorphisms. The gene discussed is VEGFA; the disease is metabolic syndrome.