Olaparib, an orally bioavailable PARP inhibitor, has been shown to cause synergistic lethality in base excision repair-deficient cells that are treated with a combination of decitabine and olaparib,28 suggesting that combination treatment of hypomethylating agents with PARP inhibitors might improve outcomes of patients with MDS or AML. This evidence concerns the gene PARP1 and acute myeloid leukemia.