Our previous in vitro study determined that OXY possesses anti-adipogenic property in 3T3-L1 cells by regulating some key transcriptional factors, as well as inducing cell cycle arrest through modulation of specific cell cycle regulatory molecules [17], which encouraged us to study the potential effect of OXY in regulating obesity in vivo. The gene discussed is GCG; the disease is obesity due to melanocortin 4 receptor deficiency.