Probasin-Cre (PB-Cre) mice were generated to drive Cre recombinase expression under the control of the probasin promoter [86,87,88] and confirmed histopathological observations of carcinoma arising in P27kip/PTEN heterozygous loss of function GEMM with non-tissue-specific loss of PTEN function [89]. Here, PTEN is linked to carcinoma.