Further, IL-6 expression in alcoholics was indicative of more severe liver disease, was correlated positively with other inflammatory mediators [IL-18, osteopontin (OPN)] and fibrotic markers [α-smooth muscle actin (α-SMA) and semaphorin 7A (SEMA7A)], and remained elevated after one week of alcohol withdrawal [87]. The gene discussed is SPP1; the disease is liver disorder.