VEGFC and metastatic malignant neoplasm in the lymph nodes: Moreover, lymphangiogenic VEGF-C and -D resulted overexpressed in a group of 50 GBC (>60%, in 32 and 31 of 50 patients, respectively) and their high expression correlated with lymph node metastasis via the nuclear factor (NF)-κB pathway [34,35], as observed in a small cohort of 20 patients.