Other inflammatory cytokines and mediators which are related to pathways in the early steps of CRC development, including arginase-1, IL-23a, IL-27, 12-lipoxygenase (LOX), and 15-LOX in the colonic mucosa, were examined as well, demonstrating that they showed no significant difference of expression levels among the three groups (Figure S1A). The gene discussed is ALOX15; the disease is colorectal carcinoma.