SMAD3 and obesity due to melanocortin 4 receptor deficiency: Relevantly, the areas under the ROC curves (AUCs) for FGFRL1, NCAPH2, PNKD, and SMAD3 evidenced excellent and statistically significant efficiencies in discriminating obesity from non-obesity in both the subcutaneous adipose tissue (Fig. 5a) and leukocytes (Fig. 5b).