Nine of these 78 CpGs were located in promoters and islands and they mapped to 11 unique genes (FGFRL1, LMF2, NCAPHR, PODXL, PIP5K1A, PNKD, PTPRCAP, RSRC2, KNTC1, SMAD3 and WDR45L) which were identified as potential target genes that could reflect the obesity state in leukocytes because they exhibited the greatest differences between the obese and non-obese samples. This evidence concerns the gene SMAD3 and obesity disorder.