Autophagy-associated ULK4(ref. 58) gene contained a rare mutation in germline DNA from a DLBCL patient.4 Another variant of ULK4 was shown to predispose to multiple myeloma and monoclonal gammopathy of undetermined significance.59 Whether Unc-51-like kinase 4 mutations also promote the development of DLBCL is by no means established yet. This evidence concerns the gene ULK4 and plasma cell myeloma.