DLBCL is not among the classical tumors in the Li–Fraumeni syndrome (LFS) caused by germline TP53 mutations.21 LFS families do harbor lymphomas, and a possible LFS patient with a germline TP53 mutation with a brain tumor and a subsequent DLBCL was reported from Japan.22 A single case report was published on the occurrence of breast cancer, ovarian cancer and DLBCL in a patient with a BRCA1 mutation.23 This evidence concerns the gene TP53 and brain neoplasm.