NFKB1 and diffuse large B-cell lymphoma: These variants are characterized as the gain-of-function polymorphisms that enhance the activity of the nuclear factor kappa B (NFkB) pathway.56 The germline H159Y mutation in TNFRSF13C may also lead, via TRAF3- and TRAF6-mediated signal transduction, to increased NFkB activity and appears to be associated with various lymphoma types including DLBCL.57