Patients of over 40 years of age have been diagnosed with compound heterozygosity for a LIG4 mutation, which can cause myelodysplasia.47 An adult patient with a homozygous congenital DNA ligase 4 mutation and non-EBV-associated DLBCL has also been reported.30 A 27-year-old woman with bilateral breast cancer and myelodysplasia was compound heterozygous for both an intronic mutation and a functional polymorphism of DCLRE1C. 48 This illustrates that patients with inherited mutations in LIG4 and DCLRE1C are not solely encountered by pediatric hematologists. This evidence concerns the gene LIG4 and breast carcinoma.