Germline mutations in genes such as POLE, WIF1 and PTEN have thus far been associated primarily with solid tumors.65, 66, 67 Inherited MSH2 mutations also predominantly predispose for solid tumors, but a germline MSH2 mutation was observed in a patient with follicular lymphoma.16 Heterozygous germline mutations in the histone methyltransferase EZH2 gene cause the so-called Weaver syndrome with increased body height as one of its salient features. This evidence concerns the gene MSH2 and follicular lymphoma.