TET2 and diffuse large B-cell lymphoma: A single putative germline TET2 mutation was seen in human DLBCL.53 The importance of a KMT2A alteration in DLBCL pathogenesis was underpinned by its segregation with the disease in a family.54 A germline heterozygous mutation in TP63 was detected in a Japanese girl with ECC (ectrodactyly, ectodermal dysplasia, clefting) syndrome type 3, who subsequently developed DLBCL.55