The finding of somatic mutations in ETV6 in DLBCL is noteworthy as germline alterations of this transcription factor were shown to cause autosomal dominant transmission of thrombocytopenia, and predisposition to diverse hematological malignancies, colon cancer, melanoma, myopathy and gastrointestinal dysmotility.70 Germline mutations in ETV6 occur in ~1% of children with Acute Lymphoblastic Leukemia.71 Here, ETV6 is linked to colonic neoplasm.