Moreover, in a small cohort of AML patients, we detected the presence of two recurrent synergistic CCC interactions, one of them being significantly higher than in normal CD34-positive blood cells, suggesting that despite the genetic complexity of AML, some therapeutic targets may be synchronous, and that only a handful of combinatorial treatments might be sufficient to treat the majority of patients without major toxicity. Here, CD34 is linked to acute myeloid leukemia.