TP53 and acute myeloid leukemia: The selective MDM2 inhibitor Nutlin-3a has been found to potently reactivate wild-type p53 and induce apoptosis in AML.32 p53 knockdown cells were significantly less sensitive to Nutlin-3a compared with control cells expressing a scrambled target sequence, indicating an efficient inhibition of p53-induced apoptosis (Figure 1d).